Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects

Ewing sarcoma (ES) is an aggressive malignancy driven by an oncogenic fusion protein, EWS-FLI1. Neuropeptide Y (NPY), and two of its receptors, Y1R and Y5R are up-regulated by EWS-FLI1 and abundantly expressed in ES cells. Paradoxically, NPY acting via Y1R and Y5R stimulates ES cell death. Here, we...

Full description

Bibliographic Details
Main Author: Lu, Congyi (Contributor)
Other Authors: McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Impact Journals/National Center for Biotechnology Information (U.S.), 2014-09-18T18:31:36Z.
Subjects:
Article
Online Access:Get fulltext

Similar Items

Similar Items