The Roles of Individual Mammalian Argonautes in RNA Interference In Vivo

The Roles of Individual Mammalian Argonautes in RNA Interference In Vivo

Argonaute 2 (Ago2) is the only mammalian Ago protein capable of mRNA cleavage. It has been reported that the activity of the short interfering RNA targeting coding sequence (CDS), but not 3' untranslated region (3'UTR) of an mRNA, is solely dependent on Ago2 in vitro. These studies utilize...

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Bibliographic Details
Main Authors: Ruda, Vera M. (Contributor), Chandwani, Rohit (Author), Sehgal, Alfica (Author), Akinc, Akin (Author), Charisse, Klaus (Author), Tarakhovsky, Alexander (Author), Novobrantseva, Tatiana I. (Author), Kotelianski, Victor E. (Contributor), Bogorad, Roman (Contributor)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-09-12T14:44:43Z.
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