Solvent Exposure Associated with Single Abasic Sites Alters the Base Sequence Dependence of Oxidation of Guanine in DNA in GG Sequence Contexts

Solvent Exposure Associated with Single Abasic Sites Alters the Base Sequence Dependence of Oxidation of Guanine in DNA in GG Sequence Contexts

The effect of exposure of guanine in double-stranded oligonucleotides to aqueous solvent during oxidation by one-electron oxidants was investigated by introducing single synthetic tetrahydrofuran-type abasic sites (Ab) either adjacent to or opposite tandem GG sequences. The selective oxidation of gu...

Full description

Bibliographic Details
Main Authors: Lee, Young-Ae (Author), Liu, Zhi (Author), Dedon, Peter C. (Contributor), Geacintov, Nicholas E. (Author), Shafirovich, Vladimir (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2014-08-18T18:28:01Z.
Subjects:
Article
Online Access:Get fulltext

Similar Items

Similar Items