Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

Recent molecular studies have shown that, even when derived from a seemingly homogenous population, individual cells can exhibit substantial differences in gene expression, protein levels and phenotypic output1, 2, 3, 4, 5, with important functional consequences4, 5. Existing studies of cellular het...

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Main Authors: Shalek, Alex K. (Author), Satija, Rahul (Author), Adiconis, Xian (Author), Gertner, Rona S. (Author), Gaublomme, Jellert T. (Author), Raychowdhury, Raktima (Author), Schwartz, Schraga (Author), Yosef, Nir (Author), Malboeuf, Christine (Author), Trombetta, John J. (Author), Gennert, David (Author), Gnirke, Andreas (Author), Goren, Alon (Author), Hacohen, Nir (Author), Levin, Joshua Z. (Author), Park, Hongkun (Author), Regev, Aviv (Contributor), Lu, Diana, Ph. D. Massachusetts Institute of Technology (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-03-14T17:23:08Z.
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