Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

Mutations in the gene isocitrate dehydrogenase 1 (IDH1) are present in up to 86% of grade II and III gliomas and secondary glioblastoma. Arginine 132 (R132) mutations in the enzyme IDH1 result in excess production of the metabolite 2-hydroxyglutarate (2HG), which could be used as a biomarker for thi...

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Main Authors: Andronesi, Ovidiu C. (Author), Kim, Grace S. (Author), Gerstner, Elizabeth R. (Author), Batchelor, Tracy T. (Author), Tzika, Aria A. (Author), Fantin, Valeria R. (Author), Vander Heiden, Matthew G. (Contributor), Sorensen, A. Gregory (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science, 2014-03-07T16:46:26Z.
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