Allosteric regulation of DegS protease subunits through a shared energy landscape
The PDZ domains of the trimeric DegS protease bind unassembled outer-membrane proteins (OMPs) that accumulate in the Escherichia coli periplasm. This cooperative binding reaction triggers a proteolytic cascade that activates a transcriptional stress response. To dissect the mechanism of allosteric a...
| Main Authors: | , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group,
2014-02-27T19:33:02Z.
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| Subjects: | |
| Online Access: | Get fulltext |