Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome

Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome

Divergent transcription occurs at the majority of RNA polymerase II (RNAPII) promoters in mouse embryonic stem cells (mESCs), and this activity correlates with CpG islands. Here we report the characterization of upstream antisense transcription in regions encoding transcription start site associated...

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Bibliographic Details
Main Authors: Flynn, Ryan A. (Contributor), Almada, Albert Ernesto (Contributor), Zamudio, Jesse Ray (Contributor), Sharp, Phillip A. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2014-02-27T16:09:56Z.
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