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|a dc
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|a Narayan, Kavitha
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|a Massachusetts Institute of Technology. Department of Biology
|e contributor
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|a Regev, Aviv
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|a Sylvia, Katelyn E.
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|a Malhotra, Nidhi
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|a Yin, Catherine C.
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|a Martens, Gregory
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|a Vallerskog, Therese
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|a Kornfeld, Hardy
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|a Xiong, Na
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|a Cohen, Nadia R.
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|a Brenner, Michael B.
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|a Berg, Leslie J.
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|a Kang, Joonsoo
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|a Immunological Genome Project Consortium
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|a Regev, Aviv
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|a Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
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|b Nature Publishing Group,
|c 2014-02-21T18:20:11Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/85068
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|a PMC 2012 November 01
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|a Innate γδ T cells function in the early phase of immune responses. Although innate γδ T cells have often been studied as one homogenous population, they can be functionally classified into effector subsets on the basis of the production of signature cytokines, analogous to adaptive helper T cell subsets. However, unlike the function of adaptive T cells, γδ effector T cell function correlates with genomically encoded T cell antigen receptor (TCR) chains, which suggests that clonal TCR selection is not the main determinant of the differentiation of γδ effector cells. A high-resolution transcriptome analysis of all emergent γδ thymocyte subsets segregated on the basis of use of the TCR γ-chain or δ-chain indicated the existence of three separate subtypes of γδ effector cells in the thymus. The immature γδ subsets were distinguished by unique transcription-factor modules that program effector function.
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|a National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (Diabetes and Endocrinology Research Center, DK32520)
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|a National Institutes of Health (U.S.) (R24 AI072073 to the ImmGen group)
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|a National Institutes of Health (U.S.) (CA100382)
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|a National Institute of Allergy and Infectious Diseases (U.S.)
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|a en_US
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|a Article
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|t Nature Immunology
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