Predictive Bcl-2 Family Binding Models Rooted in Experiment or Structure

Predictive Bcl-2 Family Binding Models Rooted in Experiment or Structure

Proteins of the Bcl-2 family either enhance or suppress programmed cell death and are centrally involved in cancer development and resistance to chemotherapy. BH3 (Bcl-2 homology 3)-only Bcl-2 proteins promote cell death by docking an α-helix into a hydrophobic groove on the surface of one or more o...

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Bibliographic Details
Main Authors: Dutta, Sanjib (Contributor), Reich, Lothar (Contributor), Keating, Amy E. (Contributor), DeBartolo, Joseph Vincent (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-01-31T17:00:23Z.
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