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84580 |
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|a dc
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|a Hynes, Richard O
|e author
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|a Massachusetts Institute of Technology. Department of Biology
|e contributor
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|a Koch Institute for Integrative Cancer Research at MIT
|e contributor
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|a Hynes, Richard O.
|e contributor
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|a Metastatic Cells Will Take Any Help They Can Get
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| 260 |
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|b Elsevier,
|c 2014-01-27T17:14:08Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/84580
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|a Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, monocyte/macrophages expressing α4 integrin bind VCAM-1 and provide survival signals enhancing establishment of metastases. Second, VCAM-1 allows dormant tumor cells to interact with osteoclasts, yielding paracrine signals and enhancing osteolytic metastatic growth.
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|a en_US
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|a Article
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|t Cancer Cell
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