Metastatic Cells Will Take Any Help They Can Get

Metastatic Cells Will Take Any Help They Can Get

Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, monocyte/macrophages expressing α4 integrin bind VCAM-1 and provide survival signals enhancing establishment of metast...

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Bibliographic Details
Main Author: Hynes, Richard O (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Hynes, Richard O. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-01-27T17:14:08Z.
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Summary:Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, monocyte/macrophages expressing α4 integrin bind VCAM-1 and provide survival signals enhancing establishment of metastases. Second, VCAM-1 allows dormant tumor cells to interact with osteoclasts, yielding paracrine signals and enhancing osteolytic metastatic growth.

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