Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate

Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate

Women with inherited mutations in the BRCA1 gene have increased risk of developing breast cancer but also exhibit a predisposition for the development of aggressive basal-like breast tumors. We report here that breast epithelial cells derived from patients harboring deleterious mutations in BRCA1 (B...

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Bibliographic Details
Main Authors: Proia, Theresa A. (Author), Keller, Patricia J. (Author), Klebba, Ina (Author), Jones, Ainsley D. (Author), Sedic, Maja (Author), Gilmore, Hannah (Author), Tung, Nadine (Author), Naber, Stephen P. (Author), Schnitt, Stuart (Author), Gupta, Piyush (Contributor), Kuperwasser, Charlotte (Author), Lander, Eric Steven (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Lander, Eric S. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-01-24T15:39:31Z.
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