RIAM, an Ena/VASP and Profilin Ligand, Interacts with Rap1-GTP and Mediates Rap1-Induced Adhesion

RIAM, an Ena/VASP and Profilin Ligand, Interacts with Rap1-GTP and Mediates Rap1-Induced Adhesion

The small GTPase Rap1 induces integrin-mediated adhesion and changes in the actin cytoskeleton. The mechanisms that mediate these effects of Rap1 are poorly understood. We have identified RIAM as a Rap1-GTP-interacting adaptor molecule. RIAM defines a family of adaptor molecules that contain a RA-li...

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Bibliographic Details
Main Authors: Lafuente, Esther M. (Author), Krause, Matthias (Contributor), Carman, Christopher V. (Author), Freeman, Gordon J. (Author), Berezovskaya, Alla (Author), Constantine, Erica (Author), Springer, Timothy A. (Author), Boussiotis, Vassiliki A. (Author), Gertler, Frank (Contributor), van Puijenbroek, Andre A.F.L (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-01-06T18:40:38Z.
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