Putting Two Heads Together to Unwind DNA

Putting Two Heads Together to Unwind DNA

The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insights into helicase loading in eukaryotes, showing that the Mcm2-7 replicative helicase encircles double-st...

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Bibliographic Details
Main Authors: Takara, Thomas J. (Author), Takara,Thomas J. (Contributor), Bell, Stephen P (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Bell, Stephen P. (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2013-12-19T20:10:52Z.
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Summary:The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insights into helicase loading in eukaryotes, showing that the Mcm2-7 replicative helicase encircles double-stranded DNA as head-to-head double hexamers.

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