Molecular mechanics of mineralized collagen fibrils in bone

• Main Authors: Nair, Arun K. (Contributor), Gautieri, Alfonso (Contributor), Chang, Shu-Wei (Contributor), Buehler, Markus J (Author)
• Other Authors: Massachusetts Institute of Technology. Center for Computational Engineering (Contributor), Massachusetts Institute of Technology. Department of Civil and Environmental Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Massachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanics (Contributor), Buehler, Markus J. (Contributor)
• Format: Article
• Language: English
• Published: Nature Publishing Group, 2013-11-25T18:22:42Z.
• Subjects: Article
• Online Access: Get fulltext

Bone is a natural composite of collagen protein and the mineral hydroxyapatite. The structure of bone is known to be important to its load-bearing characteristics, but relatively little is known about this structure or the mechanism that govern deformation at the molecular scale. Here we perform full-atomistic calculations of the three-dimensional molecular structure of a mineralized collagen protein matrix to try to better understand its mechanical characteristics under tensile loading at various mineral densities. We find that as the mineral density increases, the tensile modulus of the network increases monotonically and well beyond that of pure collagen fibrils. Our results suggest that the mineral crystals within this network bears up to four times the stress of the collagen fibrils, whereas the collagen is predominantly responsible for the material's deformation response. These findings reveal the mechanism by which bone is able to achieve superior energy dissipation and fracture resistance characteristics beyond its individual constituents.
United States. Office of Naval Research (N000141010562)
United States. Army Research Office (W991NF-09-1-0541)
United States. Army Research Office (W911NF-10-1-0127)
National Science Foundation (U.S.) (CMMI-0642545)