Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic therapies-which 'normalize' the abnormal blood vessels in tumours by making...

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Bibliographic Details
Main Authors: Chauhan, Vikash P. (Author), Stylianopoulos, Triantafyllos (Author), Chen, Ou (Contributor), Kamoun, Walid S. (Author), Bawendi, Moungi G. (Contributor), Fukumura, Dai (Author), Jain, Rakesh K. (Author), Martin, John Daniel (Contributor), Popovic, Zoran (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2013-11-04T20:15:36Z.
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Online Access:Get fulltext

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