Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes

• Main Authors: Shen, Xiaoqiang (Contributor), Buchwald, Stephen Leffler (Contributor)
• Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
• Format: Article
• Language: English
• Published: Wiley Blackwell, 2013-11-01T15:04:16Z.
• Subjects: Article
• Online Access: Get fulltext

One for the Rh(oad): The first rhodium-catalyzed asymmetric intramolecular hydroamination of unactivated olefins was developed by using dialkylbiaryl phosphine ligands (see scheme; cod=1,5-cyclooctadiene, Cy=cyclohexyl). A variety of 2-methylpyrrolidines have been synthesized with high enantioselectivities.
National Institutes of Health (U.S.) (Grant GM46059)
Merck & Co.
Boehringer Ingelheim Pharmaceuticals
National Institutes of Health (U.S.) (GM 1S10RR13886-01)