Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

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Fragile X syndrome (FXS) is the most common inherited form of autism and intellectual disability and is caused by the silencing of a single gene, fragile X mental retardation 1 (Fmr1). The Fmr1 KO mouse displays phenotypes similar to symptoms in the human condition-including hyperactivity, repetitiv...

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Main Authors: Govindarajan, Arvind (Contributor), Tonegawa, Susumu (Contributor), Dolan, Bridget M. (Contributor), Lin, Gregory G. (Contributor), Duron, Sergio G. (Author), Campbell, David A. (Author), Vollrath, Benedikt (Author), Rao, B. S. Shankaranarayana (Author), Ko, Hui-Yeon (Author), Choi, Se-Young (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor), RIKEN-MIT Center for Neural Circuit Genetics (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2013-10-03T16:21:54Z.
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