Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer cell survival. We show that, in human lung cancer cells, acute increases in intracellular concentrations of ROS caused inhibition of the glycolytic enzyme pyruvate kinase M2 (PKM2) through oxidation of Cys[s...

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Bibliographic Details
Main Authors: Vander Heiden, Matthew G. (Contributor), Anastasiou, Dimitrios (Author), Poulogiannis, George (Author), Asara, John M. (Author), Boxer, Matthew B. (Author), Jiang, Jian-kang (Author), Shen, Min (Author), Gary, Bellinger (Author), Sasaki, Atsuo T. (Author), Locasale, Jason W. (Author), Auld, Douglas S. (Author), Thomas, Craig J. (Author), Cantley, Lewis C. (Author), Bellinger, Gary (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2013-09-27T13:09:40Z.
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