350-μm side-view optical probe for imaging the murine brain in vivo from the cortex to the hypothalamus
Miniature endoscopic probes offer a solution for deep brain imaging by overcoming the limited depth of intravital microscopy. We describe a small-diameter (350 μm) graded-index optical probe with a side-view design for in vivo cellular imaging of the mammalian brain. The side-view probe provides a u...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
SPIE,
2013-08-30T15:04:18Z.
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| Subjects: | |
| Online Access: | Get fulltext |
| Summary: | Miniature endoscopic probes offer a solution for deep brain imaging by overcoming the limited depth of intravital microscopy. We describe a small-diameter (350 μm) graded-index optical probe with a side-view design for in vivo cellular imaging of the mammalian brain. The side-view probe provides a unique view of the vertical network of neurons and penetrating blood vessels. At a given insertion site, the translational and rotational scanning of the probe provides access to a large tissue area (>1 mm[superscript 2]) across the cortex, hippocampus, thalamus, and hypothalamus. United States. Dept. of Defense (Grant FA9550-10-1-0537) |
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