De novo creation of MG1655-derived E. coli strains specifically designed for plasmid DNA production
The interest in plasmid DNA (pDNA) as a biopharmaceutical has been increasing over the last several years, especially after the approval of the first DNA vaccines. New pDNA production strains have been created by rationally mutating genes selected on the basis of Escherichia coli central metabolism...
| Main Authors: | , , , |
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| Other Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Springer-Verlag,
2013-08-12T19:29:36Z.
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| Subjects: | |
| Online Access: | Get fulltext |