Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

The ability to artificially control transcription is essential both to the study of gene function and to the construction of synthetic gene networks with desired properties. Cas9 is an RNA-guided double-stranded DNA nuclease that participates in the CRISPR-Cas immune defense against prokaryotic viru...

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Bibliographic Details
Main Authors: Zhang, Feng (Contributor), Bikard, David (Author), Jiang, Wenyan (Author), Samai, Poulami (Author), Hochschild, Ann (Author), Marraffini, Luciano A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Oxford University Press, 2013-07-31T17:56:54Z.
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