|
|
|
|
LEADER |
03952 am a22005533u 4500 |
001 |
79629 |
042 |
|
|
|a dc
|
100 |
1 |
0 |
|a Cho, Woo-Kyung
|e author
|
100 |
1 |
0 |
|a Massachusetts Institute of Technology. Institute for Medical Engineering & Science
|e contributor
|
100 |
1 |
0 |
|a Whitaker College of Health Sciences and Technology
|e contributor
|
100 |
1 |
0 |
|a Harvard University-
|e contributor
|
100 |
1 |
0 |
|a Massachusetts Institute of Technology. Department of Mechanical Engineering
|e contributor
|
100 |
1 |
0 |
|a Cho, Woo-Kyung
|e contributor
|
100 |
1 |
0 |
|a Ankrum, James Allen
|e contributor
|
100 |
1 |
0 |
|a Chester, Shawn Alexander
|e contributor
|
100 |
1 |
0 |
|a Yang, Seung Yun
|e contributor
|
100 |
1 |
0 |
|a Karnik, Rohit
|e contributor
|
100 |
1 |
0 |
|a Langer, Robert
|e contributor
|
100 |
1 |
0 |
|a Karp, Jeffrey Michael
|e contributor
|
700 |
1 |
0 |
|a Ankrum, James Allen
|e author
|
700 |
1 |
0 |
|a Guo, Dagang
|e author
|
700 |
1 |
0 |
|a Chester, Shawn Alexander
|e author
|
700 |
1 |
0 |
|a Yang, Seung Yun
|e author
|
700 |
1 |
0 |
|a Campbell, Georgina A.
|e author
|
700 |
1 |
0 |
|a Wood, Robert J.
|e author
|
700 |
1 |
0 |
|a Rijal, Ram K.
|e author
|
700 |
1 |
0 |
|a Karnik, Rohit
|e author
|
700 |
1 |
0 |
|a Langer, Robert
|e author
|
700 |
1 |
0 |
|a Karp, Jeffrey Michael
|e author
|
700 |
1 |
0 |
|a Kashyap, Anurag, M. Eng. Massachusetts Institute of Technology
|e author
|
245 |
0 |
0 |
|a Microstructured barbs on the North American porcupine quill enable easy tissue penetration and difficult removal
|
260 |
|
|
|b National Academy of Sciences (U.S.),
|c 2013-07-18T20:44:50Z.
|
856 |
|
|
|z Get fulltext
|u http://hdl.handle.net/1721.1/79629
|
520 |
|
|
|a North American porcupines are well known for their specialized hairs, or quills that feature microscopic backward-facing deployable barbs that are used in self-defense. Herein we show that the natural quill's geometry enables easy penetration and high tissue adhesion where the barbs specifically contribute to adhesion and unexpectedly, dramatically reduce the force required to penetrate tissue. Reduced penetration force is achieved by topography that appears to create stress concentrations along regions of the quill where the cross sectional diameter grows rapidly, facilitating cutting of the tissue. Barbs located near the first geometrical transition zone exhibit the most substantial impact on minimizing the force required for penetration. Barbs at the tip of the quill independently exhibit the greatest impact on tissue adhesion force and the cooperation between barbs in the 0-2 mm and 2-4 mm regions appears critical to enhance tissue adhesion force. The dual functions of barbs were reproduced with replica molded synthetic polyurethane quills. These findings should serve as the basis for the development of bio-inspired devices such as tissue adhesives or needles, trocars, and vascular tunnelers where minimizing the penetration force is important to prevent collateral damage.
|
520 |
|
|
|a National Institutes of Health (U.S.) (Grant GM086433)
|
520 |
|
|
|a American Heart Association (Grant 0835601D)
|
520 |
|
|
|a National Science Foundation (U.S.) (Grant NIRT 0609182)
|
520 |
|
|
|a National Institutes of Health (U.S.) (NIH Grant DE013023)
|
520 |
|
|
|a National Research Foundation of Korea (Grant NRF-2010-357-D00277)
|
520 |
|
|
|a National Science Foundation (U.S.) (Graduate Research Fellowship Program)
|
520 |
|
|
|a National Natural Science Foundation (China) (no: 51273159)
|
520 |
|
|
|a National Natural Science Foundation (China) (no. 51072159)
|
520 |
|
|
|a China. Ministry of Education (Program for New Century Excellent Talents in Universities, 2301G107aaa)
|
520 |
|
|
|a China. Ministry of Education (Program for New Century Excellent Talents in Universities, NCET-08-0444)
|
520 |
|
|
|a China Scholarship Council
|
520 |
|
|
|a Massachusetts Institute of Technology. Undergraduate Research Opportunities Program
|
546 |
|
|
|a en_US
|
655 |
7 |
|
|a Article
|
773 |
|
|
|t Proceedings of the National Academy of Sciences
|