The functions and consequences of force at kinetochores

• Main Authors: Rago, Florencia (Contributor), Cheeseman, Iain M (Author)
• Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. School of Science (Contributor), Whitehead Institute for Biomedical Research (Contributor), Cheeseman, Iain McPherson (Contributor)
• Format: Article
• Language: English
• Published: Rockefeller University Press, The, 2013-04-25T17:29:04Z.
• Subjects: Article
• Online Access: Get fulltext

Chromosome segregation requires the generation of force at the kinetochore-the multiprotein structure that facilitates attachment of chromosomes to spindle microtubules. This force is required both to move chromosomes and to signal the formation of proper bioriented attachments. To understand the role of force in these processes, it is critical to define how force is generated at kinetochores, the contributions of this force to chromosome movement, and how the kinetochore is structured and organized to withstand and respond to force. Classical studies and recent work provide a framework to dissect the mechanisms, functions, and consequences of force at kinetochores.
National Institute of General Medical Sciences (U.S.) (Grant GM088313)