Evolving a robust signal transduction pathway from weak cross-talk

Evolving a robust signal transduction pathway from weak cross-talk

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We have evolved a robust two-component signal transduction pathway from a sensor kinase (SK) and non-partner response regulator (RR) that show weak cross-talk in vitro and no detectable cross-talk in vivo in wild-type strains. The SK, CpxA, is bifunctional, with both kinase and phosphatase activitie...

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Bibliographic Details
Main Authors: Siryaporn, Albert (Author), Perchuk, Barrett (Contributor), Laub, Michael T (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Laub, Michael T. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2013-03-27T15:14:50Z.
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