Pathological crystallization of human immunoglobulins

Pathological crystallization of human immunoglobulins

Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multiple myeloma. These cryoglobulins form crystals, and we measured their solubility lines. Depending o...

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Bibliographic Details
Main Authors: Wang, Ying (Contributor), Lomakin, Aleksey (Contributor), Hideshima, Teru (Author), Laubach, Jacob P. (Author), Ogun, Olutayo (Contributor), Richardson, Paul G. (Author), Munshi, Nikhil C. (Author), Anderson, Kenneth C. (Author), Benedek, George B. (Contributor)
Other Authors: MIT Materials Research Laboratory (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2013-03-05T22:00:20Z.
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Summary:Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multiple myeloma. These cryoglobulins form crystals, and we measured their solubility lines. Depending on the supersaturation, we observed a variety of condensate morphologies consistent with those reported in clinical investigations. Remarkably, the crystallization can occur at quite low concentrations. This suggests that, even within the regular immune response to infections, cryoprecipitation of Ig can be possible.

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