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77244 |
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|a Paparcone, Raffaella
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|a Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
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|a Massachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanics
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|a Paparcone, Raffaella
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|a Buehler, Markus J.
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|a Buehler, Markus J
|e author
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|a Microscale structural model of Alzheimer Aβ(1-40) amyloid fibril
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|b American Institute of Physics (AIP),
|c 2013-02-28T19:48:56Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/77244
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|a Amyloid fibril formation and characterization are crucial due to their association with severe degenerative disorders such as Alzheimer's, type II diabetes, and Parkinson's disease. Here we present an atomistic-based multiscale analysis, utilized to predict the structure of Alzheimer Aβ(1-40) fibrils. Our study provides a structural model of amyloid fibers with lengths of hundreds of nanometers at atomistic resolution. We report a systematic analysis of the energies, structural changes and H-bonding for varying fibril lengths, elucidating their size dependent properties. Our model predicts the formation of twisted amyloid microfibers with a periodicity of ≈82 nm, in close agreement with experimental results.
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|a United States. Office of Naval Research (Grant NN00014-08-1-0844)
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|a en_US
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|a Article
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|t Applied Physics Letters
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