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01112 am a22001693u 4500 |
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76702 |
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|a dc
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|a Browne, Edward P.
|e author
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|a Koch Institute for Integrative Cancer Research at MIT
|e contributor
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|a Browne, Edward P.
|e contributor
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|a Toll Like receptor 7 regulates viral loads and cytokine secretion during acute retroviral infection
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|b Biomed Central Ltd.,
|c 2013-01-31T16:28:21Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/76702
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|a Background: Acute HIV infection is characterized by a high viremia accompanied by a powerful wave of pro-inflammatory cytokines that affects the subsequent course of infection and pathogenesis. Thus, understanding the mechanisms that regulate cytokine secretion and viremia is a key priority. The innate immune receptor TLR7 has been identified a retrovirus-sensing protein, and is expressed in several key immune lineages. In vitro data suggests that HIV can trigger TLR7-dependent innate immune responses, but TLR7s role in vivo is unclear.
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|a en_US
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|a Article
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|t Retrovirology
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