Toll Like receptor 7 regulates viral loads and cytokine secretion during acute retroviral infection
Background: Acute HIV infection is characterized by a high viremia accompanied by a powerful wave of pro-inflammatory cytokines that affects the subsequent course of infection and pathogenesis. Thus, understanding the mechanisms that regulate cytokine secretion and viremia is a key priority. The inn...
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| Format: | Article |
| Language: | English |
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Biomed Central Ltd.,
2013-01-31T16:28:21Z.
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| Online Access: | Get fulltext |
| Summary: | Background: Acute HIV infection is characterized by a high viremia accompanied by a powerful wave of pro-inflammatory cytokines that affects the subsequent course of infection and pathogenesis. Thus, understanding the mechanisms that regulate cytokine secretion and viremia is a key priority. The innate immune receptor TLR7 has been identified a retrovirus-sensing protein, and is expressed in several key immune lineages. In vitro data suggests that HIV can trigger TLR7-dependent innate immune responses, but TLR7s role in vivo is unclear. |
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