Three-Dimensional Genome Architecture Influences Partner Selection for Chromosomal Translocations in Human Disease

Three-Dimensional Genome Architecture Influences Partner Selection for Chromosomal Translocations in Human Disease

Chromosomal translocations are frequent features of cancer genomes that contribute to disease progression. These rearrangements result from formation and illegitimate repair of DNA double-strand breaks (DSBs), a process that requires spatial colocalization of chromosomal breakpoints. The "conta...

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Bibliographic Details
Main Authors: Engreitz, Jesse Michael (Contributor), Agarwala, Vineeta (Contributor), Mirny, Leonid A. (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2013-01-28T14:59:30Z.
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