Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

Bring your own copper: Copper-chelating azides undergo much faster click reactions (CuAAC) than nonchelating azides under a variety of biocompatible conditions. This kinetic enhancement allows site-specific protein labeling to be performed on the surface of living cells with only 10-40 μM Cu[supersc...

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Bibliographic Details
Main Authors: Uttamapinant, Chayasith (Contributor), Tangpeerachaikul, Anupong (Contributor), Grecian, Scott (Author), Clarke, Scott M. (Author), Singh, Upinder (Author), Slade, Peter (Author), Gee, Kyle R. (Author), Ting, Alice Y. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2012-11-05T20:25:58Z.
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