Optical Trapping with High Forces Reveals Unexpected Behaviors of Prion Fibrils
Amyloid fibrils are important in diverse cellular functions, feature in many human diseases and have potential applications in nanotechnology. Here we describe methods that combine optical trapping and fluorescent imaging to characterize the forces that govern the integrity of amyloid fibrils formed...
Main Authors: | Dong, Jijun (Author), Castro, Carlos E. (Contributor), Boyce, Mary Cunningham (Contributor), Lang, Matthew J. (Contributor), Lindquist, Susan (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor) |
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group,
2012-10-18T17:20:29Z.
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Subjects: | |
Online Access: | Get fulltext |
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