Optical Trapping with High Forces Reveals Unexpected Behaviors of Prion Fibrils

Optical Trapping with High Forces Reveals Unexpected Behaviors of Prion Fibrils

Amyloid fibrils are important in diverse cellular functions, feature in many human diseases and have potential applications in nanotechnology. Here we describe methods that combine optical trapping and fluorescent imaging to characterize the forces that govern the integrity of amyloid fibrils formed...

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Bibliographic Details
Main Authors: Dong, Jijun (Author), Castro, Carlos E. (Contributor), Boyce, Mary Cunningham (Contributor), Lang, Matthew J. (Contributor), Lindquist, Susan (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2012-10-18T17:20:29Z.
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