Discovering Regulatory Overlapping RNA Transcripts

STEREO is a novel algorithm that discovers cis-regulatory RNA interactions by assembling complete and potentially overlapping same-strand RNA transcripts from tiling expression data. STEREO first identifies coherent segments of transcription and then discovers individual transcripts that are consist...

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Bibliographic Details
Main Authors: Danford, Timothy William (Contributor), Dowell, Robin D. (Contributor), Agarwala, Sundeep (Contributor), Grisafi, Paula (Contributor), Fink, Gerald R. (Contributor), Gifford, David K. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Springer Berlin/Heidelberg, 2012-10-09T17:25:47Z.
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Online Access:Get fulltext
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100 1 0 |a Danford, Timothy William  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Biology  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science  |e contributor 
100 1 0 |a Whitehead Institute for Biomedical Research  |e contributor 
100 1 0 |a Danford, Timothy William  |e contributor 
100 1 0 |a Dowell, Robin D.  |e contributor 
100 1 0 |a Agarwala, Sundeep  |e contributor 
100 1 0 |a Grisafi, Paula  |e contributor 
100 1 0 |a Fink, Gerald R.  |e contributor 
100 1 0 |a Gifford, David K.  |e contributor 
700 1 0 |a Dowell, Robin D.  |e author 
700 1 0 |a Agarwala, Sundeep  |e author 
700 1 0 |a Grisafi, Paula  |e author 
700 1 0 |a Fink, Gerald R.  |e author 
700 1 0 |a Gifford, David K.  |e author 
245 0 0 |a Discovering Regulatory Overlapping RNA Transcripts 
260 |b Springer Berlin/Heidelberg,   |c 2012-10-09T17:25:47Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/73688 
520 |a STEREO is a novel algorithm that discovers cis-regulatory RNA interactions by assembling complete and potentially overlapping same-strand RNA transcripts from tiling expression data. STEREO first identifies coherent segments of transcription and then discovers individual transcripts that are consistent with the observed segments given intensity and shape constraints. We used STEREO to identify 1446 regions of overlapping transcription in two strains of yeast, including transcripts that comprise a new form of molecular toggle switch that controls gene variegation. 
546 |a en_US 
655 7 |a Article 
773 |t Research in Computational Molecular Biology