Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of...

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Bibliographic Details
Main Authors: Srinivasan, Vivek J. (Author), Sakadžic, Sava (Author), Gorczynska, Iwona (Contributor), Ruvinskaya, Svetlana (Author), Wu, Weicheng (Author), Fujimoto, James G. (Contributor), Boas, David A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Optical Society of America, 2012-09-07T15:32:38Z.
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Online Access:Get fulltext
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100 1 0 |a Srinivasan, Vivek J.  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science  |e contributor 
100 1 0 |a Fujimoto, James G.  |e contributor 
100 1 0 |a Gorczynska, Iwona  |e contributor 
100 1 0 |a Fujimoto, James G.  |e contributor 
700 1 0 |a Sakadžic, Sava  |e author 
700 1 0 |a Gorczynska, Iwona  |e author 
700 1 0 |a Ruvinskaya, Svetlana  |e author 
700 1 0 |a Wu, Weicheng  |e author 
700 1 0 |a Fujimoto, James G.  |e author 
700 1 0 |a Boas, David A.  |e author 
245 0 0 |a Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography 
260 |b Optical Society of America,   |c 2012-09-07T15:32:38Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/72569 
520 |a We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level. 
520 |a National Institutes of Health (U.S.) (R01-NS057476) 
520 |a National Institutes of Health (U.S.) (P01NS055104) 
520 |a National Institutes of Health (U.S.) (P50NS010828) 
520 |a National Institutes of Health (U.S.) (K99NS067050) 
520 |a National Institutes of Health (U.S.) (R01-CA075289-12) 
520 |a United States. Air Force Office of Scientific Research (FA9550-07-1-0014) 
520 |a United States. Dept. of Defense. Medical Free Electron Laser Program (FA9550-07-1-0101) 
546 |a en_US 
655 7 |a Article 
773 |t Optics Letters