Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

• Main Authors: Srinivasan, Vivek J. (Author), Sakadžic, Sava (Author), Gorczynska, Iwona (Contributor), Ruvinskaya, Svetlana (Author), Wu, Weicheng (Author), Fujimoto, James G. (Contributor), Boas, David A. (Author)
• Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
• Format: Article
• Language: English
• Published: Optical Society of America, 2012-09-07T15:32:38Z.
• Subjects: Article
• Online Access: Get fulltext

We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.
National Institutes of Health (U.S.) (R01-NS057476)
National Institutes of Health (U.S.) (P01NS055104)
National Institutes of Health (U.S.) (P50NS010828)
National Institutes of Health (U.S.) (K99NS067050)
National Institutes of Health (U.S.) (R01-CA075289-12)
United States. Air Force Office of Scientific Research (FA9550-07-1-0014)
United States. Dept. of Defense. Medical Free Electron Laser Program (FA9550-07-1-0101)