Nanofluidic Concentration Device for Biomolecules Utilizing Ion Concentration Polarization: Theory, Fabrication, and Applications

• Main Authors: Kim, Sung Jae (Author), Song, Yong-Ak (Author), Han, Jongyoon (Contributor)
• Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
• Format: Article
• Language: English
• Published: Royal Society of Chemistry, 2012-07-26T14:48:43Z.
• Subjects: Article
• Online Access: Get fulltext

This article was published as part of the From microfluidic application to nanofluidic phenomena issue
Recently, a new type of electrokinetic concentration devices has been developed in a microfluidic chip format, which allows efficient trapping and concentration of biomolecules by utilizing ion concentration polarization near nanofluidic structures. These devices have drawn much attention not only due to their potential application in biomolecule sensing, but also due to the rich scientific content related to ion concentration polarization, the underlying physical phenomenon for the operation of these electrokinetic concentration devices. This tutorial review provides an introduction to the scientific and engineering advances achieved, in-depth discussion about several interesting applications of these unique concentration devices, and their current limitations and challenges.
National Science Foundation (U.S.) (CBET-0347348 & 0854026)
National Institutes of Health (U.S.) (Grant EB005743)
National Institutes of Health (U.S.) (Grant CA119402)
National Institutes of Health (U.S.) (Grant P50-GM68762)