Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of beta-Secretase (BACE1)

Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of beta-Secretase (BACE1)

Alzheimer's disease (AD) is the most common cause of dementia, and is characterized by memory loss and cognitive decline, as well as amyloid β (Aβ) accumulation, and progressive neurodegeneration. Cdk5 is a proline-directed serine/threonine kinase whose activation by the p25 protein has been im...

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Main Authors: Giusti-Rodriguez, Paola (Contributor), Gao, Jun (Contributor), Graff, Johannes (Contributor), Rei, Damien (Contributor), Soda, Takahiro (Contributor), Tsai, Li-Huei (Contributor)
Other Authors: move to dc.description.sponsorship (Contributor), Whitaker College of Health Sciences and Technology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Society for Neuroscience, 2012-06-27T17:50:26Z.
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