Dimerization of functional pyrroloindolizines for the synthesis of complex myrmicarin alkaloids

• Main Authors: Ondrus, Alison E. (Contributor), Kaniskan, Husnu Umit (Contributor), Movassaghi, Mohammad (Contributor)
• Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
• Format: Article
• Language: English
• Published: Elsevier B.V., 2012-06-21T18:37:20Z.
• Subjects: Article
• Online Access: Get fulltext

The union of functionalized pyrroloindolizines for the synthesis of heterodimeric products relevant to myrmicarin alkaloids is described. Design and synthesis of tricyclic substrates and new methods for their union enable the investigation of late-stage cyclopentannulation strategies. The rapid assembly of dimeric structures using unique modes of pyrroloindolizine reactivity presents a concise approach to the dimeric myrmicarins and relevant derivatives.
National Institutes of Health (U.S.) (NIH-NIGMS (GM074825))
Alfred P. Sloan Foundation (Research Fellowship)
Henry & Camille Dreyfus Foundation (Teacher-Scholar)
Novartis (Firm) (Graduate Fellowship)