In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

Recent studies have demonstrated a simple, potentially universal strategy to enhance vaccine potency, via intralymph node (i.LN) injection. To date, intranodal immunization studies have focused on the delivery of unadjuvanted vaccines (e.g., naked DNA, peptide, or protein). We hypothesized that comb...

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Bibliographic Details
Main Authors: Jewell, Christopher M. (Contributor), Irvine, Darrell J (Author), Bustamante Lopez, Sandra C (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Irvine, Darrell J. (Contributor), Bustamante Lopez, Sandra C. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences, 2012-04-13T16:47:46Z.
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