Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities
Cytoplasmic viral RNAs with 5' triphosphates (5'ppp) are detected by the RNA helicase RIG-I, initiating downstream signaling and alpha/beta interferon (IFN-α/β) expression that establish an antiviral state. We demonstrate here that the hepatitis C virus (HCV) 3' untranslated region (U...
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology,
2012-03-28T19:20:47Z.
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| Subjects: | |
| Online Access: | Get fulltext |