Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

In yeast, Sir2 family proteins (sirtuins) regulate gene silencing, recombination, DNA repair, and aging via histone deacetylation. Most of the seven mammalian sirtuins (Sirt1-Sirt7) have been implicated as NAD+-dependent protein deacetylases with targets ranging from transcriptional regulators to me...

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Main Authors: Schwer, Bjoern (Author), Schumacher, Bjoern (Author), Lombard, David B. (Author), Xiao, Cuiying (Author), Kurtev, Martin V. (Author), Gao, Jun (Contributor), Schneider, Jennifer I. (Author), Chai, Hua (Author), Bronson, Roderick T. (Author), Tsai, Li-Huei (Contributor), Deng, Chu-Xia (Author), Alt, Frederick W. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2011-08-26T18:48:33Z.
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