Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival bearing tumors derived from Brca1-deficient ovarian cancer cells

Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival bearing tumors derived from Brca1-deficient ovarian cancer cells

Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP1) with small molecules has been shown to be an effective treatment for ovarian cancer with BRCA mutations. Here, we report the in vivo administration of siRNA to Parp1 in mouse models of ovarian cancer. A unique member of the li...

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Bibliographic Details
Main Authors: Goldberg, Michael Solomon (Contributor), Xing, Deyin (Contributor), Ren, Yin (Contributor), Orsulic, Sandra (Author), Sharp, Phillip A. (Contributor), Bhatia, Sangeeta N (Author)
Other Authors: Whitaker College of Health Sciences and Technology (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Bhatia, Sangeeta N. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2011-08-23T15:01:51Z.
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