Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

Ubiquitin-dependent processes control much of cellular physiology. We show that expression of a highly active, Epstein-Barr virus-derived deubiquitylating enzyme (EBV-DUB) blocks proteasomal degradation of cytosolic and ER-derived proteins by preemptive removal of ubiquitin from proteasome substrate...

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Bibliographic Details
Main Authors: Ernst, Robert (Author), Claessen, Jasper H. L. (Author), Mueller, Britta (Author), Sanyal, Sumana (Author), Spooner, Eric (Author), van der Veen, Annemarthe G. (Author), Kirak, Oktay (Author), Schlieker, Christian D. (Author), Weihofen, Wilhelm A. (Author), Ploegh, Hidde (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2011-08-19T14:46:58Z.
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