The Current Concept of T[subscript H]17 Cells and Their Expanding Role in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a multifaceted range of symptoms affecting almost every organ system. The prototypical pathology of SLE involves the production of antinuclear antibodies and the deposition of immune complexes in basement membranes throughout th...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Pub. Corp.,
2011-08-11T15:13:39Z.
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| Subjects: | |
| Online Access: | Get fulltext |
| Summary: | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a multifaceted range of symptoms affecting almost every organ system. The prototypical pathology of SLE involves the production of antinuclear antibodies and the deposition of immune complexes in basement membranes throughout the body where they induce inflammatory responses. The genetic and environmental etiologies of this process are being intensively sought, and recently, TH17 cells have been implicated in the pathogenesis of SLE. TH17 cells are CD4+ memory T cells that behave as both helper and effector cell populations functioning through their signature IL-17 cytokines. Their differentiation is distinct to either the TH1 or TH2 cell lineage, but strongly influences development of adaptive responses, including autoimmunity. This paper details the biological functions and regulation of TH17 cells, followed by an update of their expanding role in SLE. National Institute of Dental and Craniofacial Research (U.S.) (PHS Grants K99DE018958) National Institute of Allergy and Infectious Diseases (U.S.) (R21AI081952) National Institute of Allergy and Infectious Diseases (U.S.) (R01AI45050) Sjogren's Syndrome Foundation University of Florida. Center for Orphaned Autoimmune Disorders |
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