Repair of DNA Alkylation Damage by the Escherichia coli Adaptive AlkB as Studied by ESI-TOF Mass Spectrometry

Repair of DNA Alkylation Damage by the Escherichia coli Adaptive AlkB as Studied by ESI-TOF Mass Spectrometry

DNA alkylation can cause mutations, epigenetic changes, and even cell death. All living organisms have evolved enzymatic and non-enzymatic strategies for repairing such alkylation damage. AlkB, one of the Escherichia coli adaptive response proteins, uses an α-ketoglutarate/Fe(II)-dependent mechanism...

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Bibliographic Details
Main Authors: Li, Deyu (Contributor), Delaney, James C. (Contributor), Page, Charlotte M. (Contributor), Chen, Alvin S. (Contributor), Wong, Cintyu (Contributor), Essigmann, John M. (Contributor), Drennan, Catherine L (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Drennan, Catherine L. (Contributor)
Format: Article
Language:English
Published: SAGE-Hindawi Access to Research, 2011-07-13T16:21:23Z.
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