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142064 |
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|a Schuppe, Alexander W
|e author
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|a Knippel, James Levi
|e author
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|a Borrajo-Calleja, Gustavo M
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|a Buchwald, Stephen L
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|a Enantioselective Hydroalkenylation of Olefins with Enol Sulfonates Enabled by Dual Copper Hydride and Palladium Catalysis
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|b American Chemical Society (ACS),
|c 2022-04-25T17:43:14Z.
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| 856 |
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|z Get fulltext
|u https://hdl.handle.net/1721.1/142064
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|a The catalytic enantioselective synthesis of α-chiral olefins represents a valuable strategy for rapid generation of structural diversity in divergent syntheses of complex targets. Herein, we report a protocol for the dual CuH- and Pd-catalyzed asymmetric Markovnikov hydroalkenylation of vinyl arenes and the anti-Markovnikov hydroalkenylation of unactivated olefins, in which readily available enol triflates can be utilized as alkenyl coupling partners. This method allowed for the synthesis of diverse α-chiral olefins, including tri- and tetrasubstituted olefin products, which are challenging to prepare by existing approaches.
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|a Article
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|t 10.1021/JACS.1C02117
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| 773 |
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|t Journal of the American Chemical Society
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