Defining and Manipulating B Cell Immunodominance Hierarchies to Elicit Broadly Neutralizing Antibody Responses against Influenza Virus

Defining and Manipulating B Cell Immunodominance Hierarchies to Elicit Broadly Neutralizing Antibody Responses against Influenza Virus

Show other versions (1)

© 2020 Elsevier Inc. The antibody repertoire possesses near-limitless diversity, enabling the adaptive immune system to accommodate essentially any antigen. However, this diversity explores the antigenic space unequally, allowing some pathogens like influenza virus to impose complex immunodominance...

Full description

Bibliographic Details
Main Authors:	Amitai, Assaf (Author), Sangesland, Maya (Author), Barnes, Ralston M (Author), Rohrer, Daniel (Author), Lonberg, Nils (Author), Lingwood, Daniel (Author), Chakraborty, Arup K (Author)
Format:	Article
Language:	English
Published:	Elsevier BV, 2022-02-10T23:09:51Z.
Subjects:	Article
Online Access:	Get fulltext

Similar Items

Defining and Manipulating B Cell Immunodominance Hierarchies to Elicit Broadly Neutralizing Antibody Responses against Influenza Virus
by: Amitai, Assaf, et al.
Published: (2022)

Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus
by: Sangesland, Maya, et al.
Published: (2020)

A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood
by: Maya Sangesland, et al.
Published: (2020-08-01)

A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood
by: Sangesland, Maya, et al.
Published: (2020)

Dynamic immunodominance hierarchy of neutralizing antibody responses to evolving GII.4 noroviruses
by: Ford-Siltz, L.A, et al.
Published: (2022)

Antibody Focusing to Conserved Sites of Vulnerability: The Immunological Pathways for ‘Universal’ Influenza Vaccines
by: Maya Sangesland, et al.
Published: (2021-02-01)

Injection of Antibodies against Immunodominant Epitopes Tunes Germinal Centers to Generate Broadly Neutralizing Antibodies
by: Michael Meyer-Hermann
Published: (2019-10-01)

Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV
by: Chakraborty, A.K, et al.
Published: (2022)

Development of an anti-HIV vaccine eliciting broadly neutralizing antibodies
by: Yousuf Ahmed, et al.
Published: (2017-09-01)

An immunodominant and immunogenetically defined polipeptide present in T. cruzi
by: R. Ramos, et al.
Published: (1988-11-01)

Broad-Based Influenza-Specific CD8<sup>+</sup> T Cell Response without the Typical Immunodominance Hierarchy and Its Potential Implication
by: Miaojuan Huang, et al.
Published: (2021-06-01)

Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
by: Deli Huang, et al.
Published: (2020-11-01)

Elicitation of broadly neutralizing antibodies against HIV-1 – the germline/maturation hypothesis
by: Prabakaran ePonraj, et al.
Published: (2014-08-01)

A Population Dynamics Model for Clonal Diversity in a Germinal Center
by: Assaf Amitai, et al.
Published: (2017-09-01)

Computational prediction of broadly neutralizing HIV-1 antibody epitopes from neutralization activity data.
by: Andrew L Ferguson, et al.
Published: (2013-01-01)

Computational Prediction of Broadly Neutralizing HIV-1 Antibody Epitopes from Neutralization Activity Data
by: Ferguson, Andrew L., et al.
Published: (2014)

Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies
by: Victor Ovchinnikov, et al.
Published: (2018-02-01)

Fc-Based Recombinant Henipavirus Vaccines Elicit Broad Neutralizing Antibody Responses in Mice
by: Yaohui Li, et al.
Published: (2020-04-01)

Eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
by: Han D, et al.
Published: (2012-09-01)

Characterization and evaluation of approaches to elicit Broadly Reactive Neutralizing Antibodies against HIV-1
by: Penn-Nicholson, Adam Garth
Published: (2008)

Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies
by: Karplus, Martin, et al.
Published: (2018)

Author Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
by: Deli Huang, et al.
Published: (2020-12-01)

Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates
by: Kevin O. Saunders, et al.
Published: (2017-02-01)

Optimal immunization cocktails can promote induction of broadly neutralizing Abs against highly mutable pathogens
by: Moore, Penny L., et al.
Published: (2017)

The low spike density of HIV may have evolved because of the effects of T helper cell depletion on affinity maturation.
by: Assaf Amitai, et al.
Published: (2018-08-01)

Immunodominance in T cell responses elicited against different domains of detoxified pneumolysin PlyD1.
by: Els van Westen, et al.
Published: (2018-01-01)

Engineering an Antibody V Gene-Selective Vaccine
by: Larance Ronsard, et al.
Published: (2021-09-01)

Early changes in the CD8 T Cell immunodominance hierarchy in primary HIV infection prior to seroconversion
by: Keane N, et al.
Published: (2012-09-01)

A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus.
by: Diogo M Magnani, et al.
Published: (2017-06-01)

Jenga: Software-Defined Cache Hierarchies
by: Tsai, Po-An, et al.
Published: (2021)

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells.
by: Sneha Sant, et al.
Published: (2020-08-01)

A Lentiviral Vector Expressing Japanese Encephalitis Virus-like Particles Elicits Broad Neutralizing Antibody Response in Pigs.
by: Mélissanne de Wispelaere, et al.
Published: (2015-01-01)

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance
by: Cirelli, Kimberly M., et al.
Published: (2020)

Myomedin scaffold variants targeted to 10E8 HIV-1 broadly neutralizing antibody mimic gp41 epitope and elicit HIV-1 virus-neutralizing sera in mice
by: Milan Kuchař, et al.
Published: (2021-01-01)

The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies.
by: Devin Sok, et al.
Published: (2013-01-01)

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
by: Sok, Devin, et al.
Published: (2014)

Influenza Hemagglutinin Nanoparticle Vaccine Elicits Broadly Neutralizing Antibodies against Structurally Distinct Domains of H3N2 HA
by: Alyse D. Portnoff, et al.
Published: (2020-02-01)

Immunodominant Mycobacterium tuberculosis Protein Rv1507A Elicits Th1 Response and Modulates Host Macrophage Effector Functions
by: Simran Kaur Arora, et al.
Published: (2020-07-01)

Functional and in silico Characterization of Neutralizing Interactions Between Antibodies and the Foot-and-Mouth Disease Virus Immunodominant Antigenic Site
by: Ruben Marrero Diaz de Villegas, et al.
Published: (2021-05-01)

Correction: The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies.
by: Devin Sok, et al.
Published: (2013-12-01)