Comprehensive identification of somatic nucleotide variants in human brain tissue

Comprehensive identification of somatic nucleotide variants in human brain tissue

Abstract Background Post-zygotic mutations incurred during DNA replication, DNA repair, and other cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of various diseases, including cancers. However, detecting mosaic variants in DNA from non-cancerous somatic tissu...

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Main Authors: Wang, Yifan (Author), Bae, Taejeong (Author), Thorpe, Jeremy (Author), Sherman, Maxwell A (Author), Jones, Attila G (Author), Cho, Sean (Author), Daily, Kenneth (Author), Dou, Yanmei (Author), Ganz, Javier (Author), Galor, Alon (Author), Lobon, Irene (Author), Pattni, Reenal (Author), Rosenbluh, Chaggai (Author), Tomasi, Simone (Author), Tomasini, Livia (Author), Yang, Xiaoxu (Author), Zhou, Bo (Author), Akbarian, Schahram (Author), Ball, Laurel L (Author), Bizzotto, Sara (Author)
Format: Article
Language:English
Published: BioMed Central, 2021-09-20T17:41:59Z.
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