Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes

Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes

Background & Aims: Patients with cirrhosis are at high risk for hepatocellular carcinoma (HCC) and often have increased serum levels of estrogen. It is not clear how estrogen promotes hepatic growth. We investigated the effects of estrogen on hepatocyte proliferation during zebrafish development...

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Main Authors: Chaturantabut, Saireudee (Author), Shwartz, Arkadi (Author), Evason, Kimberley J. (Author), Cox, Andrew G. (Author), Labella, Kyle (Author), Schepers, Arnout (Author), Yang, Song (Author), Acuña, Mariana (Author), Houvras, Yariv (Author), Mancio Silva, Liliana (Author), Romano, Shannon (Author), Gorelick, Daniel A. (Author), Cohen, David E. (Author), Zon, Leonard I. (Author), Bhatia, Sangeeta N. (Author), North, Trista E. (Author), Goessling, Wolfram (Author), Bhatia, Sangeeta N (Author)
Other Authors: Harvard University- (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-12-04T21:43:12Z.
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